Difference between Ginsenoside and Ginsenoside Rh2

- Jan 07, 2019 -

Ginsenoside Rh2 is one of the ginsenoside monomers. But it is not entirely such a simple attribution relationship.

Ginsenoside Rh2 is a protopanaxadiol-type low-sugar chain saponin monomer isolated from Panax ginseng. Initially, when ginseng was exposed to sun, the secondary saponins were produced by the breakdown and degradation of sugar chains on the ligands due to the thermal decomposition of some protopanaxadiol group ginsenosides. Extraction of ginsenoside Rh2: Secondary ginsenoside, which can only be achieved by degradation. The common degradation methods include photodegradation, acid-catalyzed degradation, alkali-catalyzed degradation, enzymatic degradation, periodic acid pyrolysis, chemical modification degradation and so on.

Ginsenoside is the general name of ginsenosides in ginseng. There are about 40 kinds of ginsenoside monomers with different functions. Ginsenoside is regarded as the active ingredient in ginseng, so it has become the research target. Ginseng saponins have similar basic structures. They all contain steroid nuclei arranged by 30 carbon atoms into four rings. They were divided into two groups according to the different glycoside structure: Dammaran and oleanolic. Ginsenoside components include: ginsenoside Rb1, Rb2, Rb3, Rc, Rd, Rg3, Rh2 and so on. Because ginsenosides affect multiple metabolic pathways, their efficacy is also complex, and the effects of various ginsenosides are difficult to isolate.

For cancer patients, ginsenoside Rh2 is a better choice, because its targeted anti-cancer effect, and through the regulation of the immune system, can also indirectly achieve anti-cancer effect. Ginsenoside and ginsenoside powder, although they also contain ginsenoside Rh2, Rg3, Rc with anti-cancer effect, but also contain some nutrients more conducive to the growth of cancer cells. Therefore, for cancer patients, the anti-cancer effect of ginsenoside and ginsenoside powder is unknown and uncertain.